Beneficial effect of skin micro-needling in the treatment of alopecia areata and its clinical assessment

• Published in: Ji chu yi xue yu lin chuang = Jichu yixue yu linchuang = Basic medical sciences and clinics Vol. 41; no. 3; pp. 393 - 397
• Main Author: PENG Ya-wen, LEI Tie-chi
• Format: Journal Article
• Language: Chinese
• Published: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College 01.03.2021
• Subjects: alopecia areata|micro-needling|efficacy|epithelial hair follicle stem cells
• ISSN: 1001-6325

Objective To investigate the effects of skin micro-needling in the treatment of alopecia areata (AA) using a dermaroller of 1.5 mm sized needles and in the stimulation of mouse dorsal hair growth using a dermaroller of 0.5 mm sized needles. Methods Fifty-two patients with AA were recruited from the outpatient department of Renmin Hospital of Wuhan University (Mar 2018 to Aug 2019) and further divided into two group, 5% minoxidil spray and 0.05% halomethasone cream were applied topically to the control group. The micro-needling group received micro-needling treatment combined with 5% minoxidil spray and 0.05% halomethasone cream. Moreover, the dorsal hair of C57BL/6 mouse was removed and then divided into model group, minoxidil group and micro-needling group. From the next day, the corresponding treatment was given to the mice for 14 consecutive days. Anagen-associated pigmentation changes and hair growth were recorded using a digital camera. The morphology and number of anagenic hair follicles were observed u