Protective effects of parthenolide on intestinal barrier function in septic rats

• Published in: Lu jun jun yi da xue xue bao Vol. 44; no. 20; pp. 2068 - 2074
• Main Authors: GUO Ningke, SHE Han, TAN Lei, ZHOU Yuanqun
• Format: Journal Article
• Language: Chinese
• Published: Editorial Office of Journal of Army Medical University 01.10.2022
• Subjects: blood inflammatory cytokine; intestinal permeability; parthenolide; sepsis
• ISSN: 2097-0927
• DOI: 10.16016/j.2097-0927.202205042

Objective To investigate the protective effects of parthenolide (PTL) on intestinal barrier function in septic rats. Methods The septic model of rats was established by cecal ligation and puncture (CLP), and SD rats (200±20 g, male/female) were randomly divided into 6 groups: normal control (NC) group, sepsis (Sep) group, conventional treatment (LR) group (lactated Ringer's solution resuscitation+dopamine+cefuroxime sodium), and parthenolide (PTL) groups (1, 5 and 10 mg/kg parthenolide respectively on the basis of LR group). The changes of arterial blood pressure, survival rate and survival time of rats in each group were observed, and the optimal concentration of parthenolide in the treatment was determined. Moreover, the effects of parthenolide (at the optimal concentration) on the intestinal permeability, intestinal pathology, inflammatory cytokine levels, as well as liver and kidney functions in septic rats were further investigated. Results As compared with the NC group, the survival rate and survival ti