Umbilical cord bloods hematopoietic stem cells ex vivo expansion (the literature review)

Umbilical cord blood (CB) is now an attractive source of hematopoietic stem cells (HSCs) for transplantation in pediatric and adult patients with various malignant and non-malignant diseases. However, its clinical application is limited by low cells numbers in graft, which correlates with delayed en...

Full description

Saved in:
Bibliographic Details
Published inOnkogematologii͡a Vol. 7; no. 1; pp. 35 - 45
Main Authors T. V. Shamanskaya, E. Yu. Osipova, S. A. Roumiantsev
Format Journal Article
LanguageRussian
Published ABV-press 01.07.2014
Subjects
cord blood
cytokines
ex vivo expansion
Online AccessGet full text

Cover

More Information
Summary:Umbilical cord blood (CB) is now an attractive source of hematopoietic stem cells (HSCs) for transplantation in pediatric and adult patients with various malignant and non-malignant diseases. However, its clinical application is limited by low cells numbers in graft, which correlates with delayed engraftment, an extension of time to platelets and neutrophils recovery and increasing risk of infectious complications. Several strategies have been suggested to overcome this limitation, one of which is obtaining a sufficient number of hematopoietic progenitor cells by ex vivo expansion. Literature review about CB HSCs expansion in given article is presented.
ISSN:1818-8346
2413-4023
DOI:10.17650/1818-8346-2012-7-1-35-45