Modern possibilities in the treatment of inflammation caused by Staphylococcus aureus biofilm with bioactive glass S53P4

• Published in: Journal of BioScience and Biotechnology Vol. 11; no. 2; pp. 89 - 93
• Main Authors: Nikoleta Ivanova, Stoyan Ivanov, Galina Yaneva, Tsonka Dimitrova, Stoyan Stoyanov, Dobri Ivanov
• Format: Journal Article
• Language: English
• Published: Plovdiv University Press 01.01.2023
• Subjects: bioactive glass; biofilm; inflammation; staphyloccocus aureus
• ISSN: 1314-6238; 1314-6246

Treatment of implant related infections after surgicalor dentalproceduresare challengingcomplicationsandmay have devastating results for patients.The ability of microorganisms to adhere and form biofilm on implant surface is one of the main reasons for treatment failure in infections. When used in human body implants provide a suitable surfacefor cell attachment and bacterial colonization. One of the most common bacteriathat is isolated in hospital-acquired infections is Staphylococcus aureus, methicillin-resistant subtype. When a biofilm is formed, bacteria acquire an arsenal of properties that allow them to survive in an adverse environment, increasing their resistance to antimicrobial agents. Recently, as treatment modalities bioactive glass is used in the treatment of infections with multiresistant bacteria types. Its mechanism of action is to stimulate osteogenesis by releasing biologically active ions and at the same time it has antibacterial functionon a number of antibiotic-resistant bacteria due to increasementin osmotic pressure and environmental pH without affecting host tissues. These properties make bioactive glass extremelly suitablefor the treatment of infectionin boneswith destruction and bone loss. The aim of the present study is to review the outcomesreported in the literature on the antimicrobial effectiveness of bioactive glass S53P4 on Staphyloccocus aureus(MRSA).