Effect of flurbiprofen axetil pretreatment on perioperative oxidative stress and Apelin in patients with diabetes mellitus

• Published in: Xīn yīxué Vol. 53; no. 4; pp. 254 - 259
• Main Author: Guo Ruimin, Fan Junbai
• Format: Journal Article
• Language: Chinese
• Published: Editorial Office of Journal of New Medicine 01.04.2022
• Subjects: type 2 diabetes mellitus|oxidative stress|inflammation|apelin|flurbiprofen axetil
• ISSN: 0253-9802
• DOI: 10.3969/j.issn.0253-9802.2022.04.006

Objective To investigate the effect of flurbiprofen axetil pretreatment on perioperative oxidative stress and Apelin in patients with type 2 diabetes mellitus. Methods A total of 100 patients scheduled to undergo spinal surgery were recruited. Among them, 65 patients with diabetes mellitus were randomly divided into the pretreatment group （n = 32） and blank control group （n = 33）. In the pretreatment group, patients were pretreated with flurbiprofen axetil injection at a dose of 1.0 mg/kg at 10 min before anesthesia induction, and those in the blank control group received routine anesthesia without pretreatment. Non-diabetic patients were assigned into the normal control group （n = 35）, who were not given with pretreatment. The changes of the serum levels of Apelin-13, Ang Ⅱ, MDA, IL-6, blood glucose were observed at preoperative （T0）, intraoperative 1 h （T1） and postoperative 1 h （T2） time points, respectively. Meantime, the white blood cell count （WBC）and neutrophil percentage（NEUT%） were compared before an