Effect of IgG anti AB antibody on the correlation analysis between the titer of blood group antibodies and total bilirubin in serum of newborns with hemolytic disease

• Published in: Zhongguo shu xue za zhi Vol. 36; no. 11; pp. 1004 - 1008
• Main Authors: Yi ZHANG, Chen CHENG, Yijing CHEN, Qun LUO, Hailong ZHUO
• Format: Journal Article
• Language: Chinese
• Published: Institute of Blood Transfusion of Chinese Academy of Medical Sciences 01.11.2023
• Subjects: abo blood group incompatibility; hemolytic disease of fetus and newborn(hdfn); hyperbilirubinemia; igg anti-ab antibody
• ISSN: 1004-549X
• DOI: 10.13303/j.cjbt.issn.1004-549x.2023.11.007

Objective To investigate the correlation between the titer of anti-A or anti-B antibodies before and after the absorption of IgG anti-AB antibodies in the serum of type O mothers with ABO hemolytic disease of fetus and newborn (ABO-HDFN) and the total bilirubin in the serum of the children. Methods Serum samples from 119 children diagnosed with ABO-HDFN and their mothers sent to the Beijing Red Cross Blood Center from January to December 2020 were selected, and clinical data of the children were collected. Three hemolysis tests and serum total bilirubin (TBIL) determination were conducted on the children. IgG anti-A or anti-B antibody titers were tested before and after the mother′s serum absorbed IgG anti-AB antibodies. Statistical analysis was conducted on the IgG antibody titers and the TBIL results of the children. The differences in TBIL results corresponding to different IgG antibody titers were compared. The Spearman test was used to analyze the correlation between the IgG anti-A or -B antibody titers