Optimization of experimental human leukemia models (review)

Actual problem of assessing immunotherapy prospects including antigenpecific cell therapy using animal models was covered in this review.Describe the various groups of currently existing animal models and methods of their creating – from different immunodeficient mice to severalvariants of tumor cel...

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Bibliographic Details
Published inOnkogematologii͡a Vol. 7; no. 4; pp. 48 - 52
Main Authors D. D. Pankov, A. G. Rumyantsev
Format Journal Article
LanguageRussian
Published ABV-press 01.07.2014
Subjects
animal models
antigen-specific cell therapy
immunodeficient mice
immunotherapy
nod/scid
nsg
wt1
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Summary:Actual problem of assessing immunotherapy prospects including antigenpecific cell therapy using animal models was covered in this review.Describe the various groups of currently existing animal models and methods of their creating – from different immunodeficient mice to severalvariants of tumor cells engraftment in them. The review addresses the possibility of tumor stem cells studying using mouse models for the leukemia treatment with adoptive cell therapy including WT1. Also issues of human leukemia cells migration and proliferation in a mice withdifferent immunodeficiency degree are discussed. To assess the potential immunotherapy efficacy comparison of immunodeficient mouse model with clinical situation in oncology patients after chemotherapy is proposed.
ISSN:1818-8346
2413-4023
DOI:10.17650/1818-8346-2012-7-4-48-52