Mediating Effect Analysis of Visceral Adiposity Index on Serum Uric Acid to Creatinine Ratio and Metabolic Syndrome in People with Normal Thyroid Function

• Published in: Zhongguo quanke yixue Vol. 25; no. 15; pp. 1850 - 1856
• Main Author: Huanxin LIU, Cuiqiao MENG, Qian NIE, Chunhong YU, Yuling XING, Zhongli WANG, Chenghao LIU, Huijuan MA
• Format: Journal Article
• Language: Chinese
• Published: Chinese General Practice Publishing House Co., Ltd 01.05.2022
• Subjects: metabolic syndrome|visceral adiposity index|serum uric acid|serum creatinine|thyroid function|mediating effect
• ISSN: 1007-9572
• DOI: 10.12114/j.issn.1007-9572.2022.02.028

Background The yearly prevalence of metabolic syndrome (MS) is increasing in China. Although the level of serum uric acid (SUA) is closely related to MS, due to the influence of renal function on SUA, standardized SUA 〔SUA/serum creatinine ratio (SUA/Scr) 〕 may be a better predictor for MS. Visceral adiposity index (VAI) , as an important indicator for estimating visceral fat accumulation, could be used to predict MS more directly. However, few studies have explored whether VAI mediates the association between SUA/Scr ratio and MS in euthyroid population. Objective To explore the mediating effect of VAI on SUA/Scr ratio and MS in people with normal thyroid function. Methods A total of 10 042 annual health examinees were selected from the Health Examination Center, Hebei General Hospital from January 2020 to June 2021. The basic demographic information, physical examination and biochemical parameters, as well as calculated SUA/Scr ratio and VAI were collected. MS was diagnosed according to the criteria recomme