Research progress of nuclear-cytoplasmic translocation in the genesis and development of tumor

Nuclear-cytoplasmic translocation is an important cause of abnormal gene localization, which occurs at various stages of tumor development and is closely related to tumor treatment and drug resistance. In this paper, the basic structure, biological function and regulatory mechanism of nuclear transl...

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Published inJi chu yi xue yu lin chuang = Jichu yixue yu linchuang = Basic medical sciences and clinics Vol. 40; no. 8; pp. 1119 - 1123
Main Author ZHOU Jie, HUANG Ying-hui
Format Journal Article
LanguageChinese
Published Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College 01.08.2020
Subjects
nuclear-cytoplasmic translocation|molecular mechanism|therapy|research progress
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Summary:Nuclear-cytoplasmic translocation is an important cause of abnormal gene localization, which occurs at various stages of tumor development and is closely related to tumor treatment and drug resistance. In this paper, the basic structure, biological function and regulatory mechanism of nuclear translocation are described, and the role of nuclear-cytoplasmic translocation in the genesis and development of tumors, as well as the progress in tumor therapy and drug resistance are further reviewed, in order to provide theoretical basis for exploring novel anti-tumor strategies.
ISSN:1001-6325