Changes of circulating anti-A/B-antibody titers during the preparation period and after AB0-incompatible living donor kidney transplantation

• Published in: Transplantologii͡a no. 2-3; pp. 48 - 53
• Main Authors: A. I. Sushkov, Ya. G. Moisyuk
• Format: Journal Article
• Language: English
• Published: N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department 01.08.2018
• Subjects: иммуноадсорбция; несовместимость по группе крови; ритуксимаб; трансплантация почки
• ISSN: 2074-0506; 2542-0909
• DOI: 10.23873/2074-0506-2011-0-2-3-48-53

Several protocols have been developed to overcome the blood group barrier in renal transplantation. In the evolution of these protocols, one of the latest steps was the combination of anti-CD20 treatment with antigen-specific immunoadsorption (IA) and intravenous immunoglobulin (IvIg). This protocol has been widespread used for AB0-incompatible transplantation in Europe. We report our first experience of five successful AB0-incompatible kidney transplantation using anti-CD20 + IA + IvIg pretransplant conditioning protocol and tacrolimus + MMF + steroids as maintenance immunosuppression. Initial anti-A/B-antidody titers were 1:16 to 1:1024. The transplantation could be performed in all cases and the grafts showed primary function.