RADIATION INDUCED BRONCIOLITIS OBLITERANS ORGANIZING PNEUMONIA (BOOP) SYNDROME AFTER RADIOTHERAPY FOR BREAST CANCER

Radiation-induced bronchiolitis obliterans organising pneumonia (BOOP) is a lung disease which is pathologically characterized by the presence of granulation tissue polyps within respiratory bronchioles and alveoler ducts and patchy areas of organizing pneumonia. Etiologic factors include infection,...

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Bibliographic Details
Published inEuropean journal of breast health Vol. 5; no. 3; pp. 157 - 161
Main Authors Gül Alço, Maktav Dinçer, Turhan Ece, Şefik İğdem, Sait Okkan
Format Journal Article
LanguageEnglish
Published Galenos Publishing House 01.07.2009
Subjects
boop syndrome
breast cancer
radiotherapy
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Summary:Radiation-induced bronchiolitis obliterans organising pneumonia (BOOP) is a lung disease which is pathologically characterized by the presence of granulation tissue polyps within respiratory bronchioles and alveoler ducts and patchy areas of organizing pneumonia. Etiologic factors include infection, drug administration, collagen vascular disease, hypersensitivity pneumonia, toxic fume inhalation, acute respiratory defi ciency syndrome, thyroiditis and radiotherapy and it may also develop idiopathic. Occurence of radiation injury in the lung outside the tangential fi elds and appearance of patchy infi ltrates in both lungs are characteristic. It is assumed that radiation exposure to lung and pleura initiates a lymphocytic stimulation which then triggers a cytokin mediated immunologic reaction and causes the injury in both lungs. We report an early breast cancer patient treated with breast conservation surgery and postoperative breast radiotherapy who later developed BOOP syndrome in both lungs.
ISSN:2587-0831