Cardiovascular benefits of moderate exercise training in Marfan syndrome: insights from an animal model

Marfan syndrome (MF) leads to aortic root dilatation and a predisposition to aortic dissection, mitral valve prolapse, and primary and secondary cardiomyopathy. Overall, regular physical exercise is recommended for a healthy lifestyle, but dynamic sports are strongly discouraged in MF patients. None...

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Bibliographic Details
Published inJournal of the American Heart Association
Main Authors Mas‐Stachurska, Aleksandra, Siegert, Anna‐Maria, Batlle, Montserrat, Gorbenko del Blanco, Darya, Meirelles, Thayna, Rubies, Cira, Bonorino, Fabio, Serra‐Peinado, Carla, Bijnens, Bart, Baudin, Julio, Sitges, Marta, Mont, Lluís, Guasch, Eduard, Egea, Gustavo
Format Journal Article
LanguageEnglish
Published Wiley 2017
Subjects
Aneurysm
Animal models
Basic
Behavioral medicine
Clinical research
Epidemiology
Exercise
Health
Human disease
Lifestyle
Prevention
Translational
Vascular disease
Wellness
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Summary:Marfan syndrome (MF) leads to aortic root dilatation and a predisposition to aortic dissection, mitral valve prolapse, and primary and secondary cardiomyopathy. Overall, regular physical exercise is recommended for a healthy lifestyle, but dynamic sports are strongly discouraged in MF patients. Nonetheless, evidence supporting this recommendation is lacking. Therefore, we studied the role of long‐term dynamic exercise of moderate intensity on the MF cardiovascular phenotype. This work was partially supported by grants from the Instituto de Salud Carlos III (PI13/01580, PI16/00703); Sociedad Española de Cardiología; National Marfan Foundation; Ministerio de Economia y Competitividad (SAF2015‐64136R, SAF2017‐83039‐R, TIN2014‐52923‐R); Fondo Europeo de Desarrollo Regional (FEDER); Agència de Gestió d'Ajuts Universitaris i de Recerca (2014SGR334); CERCA Programme/Generalitat de Catalunya and Centro de Investigación Biomédica en RED (CIBERCV 16/11/00354).
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.117.006438