Respiratory chain dysfunction associated with multiple mitochondrial DNA deletions in antiretroviral therapy-related lipodystrophy

Highly-active antiretroviral therapy (HAART) can induce a characteristic lipodystrophy syndrome characterized by peripheral fat wasting and central adiposity, usually associated with hyperlipidaemia and insulin resistance [1,2]. Indirect data have led some authors to propose that mitochondrial dysfu...

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Bibliographic Details
Published inAIDS (London)
Main Authors Miró, Òscar, Gómez, Montserrat, Pedrol, Enric, Cardellach, Francesc, Nunes Martínez, Virginia, Casademont i Pou, Jordi
Format Journal Article
LanguageEnglish
Published Lippincott Williams & Wilkins 03.05.2013
Subjects
Antiretroviral agents
Antiretrovirals
HIV infections
Infeccions per VIH
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Summary:Highly-active antiretroviral therapy (HAART) can induce a characteristic lipodystrophy syndrome characterized by peripheral fat wasting and central adiposity, usually associated with hyperlipidaemia and insulin resistance [1,2]. Indirect data have led some authors to propose that mitochondrial dysfunction could play a role in this syndrome [3,4].To date, as recently outlined by Kakuda et al. [5] in this journal, HIV-infected patients developing lipodystrophy have not been studied for mitochondrial changes or respiratory chain capacity...
ISSN:0269-9370