Chemical Constituents from Wood of Zanthoxylum rigidum Hum. and Bonpl. Ex Willd (Rutaceae) and Antileishmanial Activities

In this study was reported the structural elucidation by means of nuclear magnetic resonance (1D and 2D), FT-IR and mass spectrometry of lupeol (1), a mixture of the steroids campesterol (2), b-sitosterol (3) and stigmasterol (4), sesamin (5), trans-dimethylmatairesinol (6), trans-methylpluviatolide...

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Published inEuropean journal of medicinal plants pp. 14 - 20
Main Authors Santos, Carlos H. C. dos, Sousa, Mayara C., Jr, Paulo T. de Sousa, Ribeiro, Tereza A. N., Jacinto, Marco J., Silva, Virgínia C. Paulino
Format Journal Article
LanguageEnglish
Published 15.07.2021
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Summary:In this study was reported the structural elucidation by means of nuclear magnetic resonance (1D and 2D), FT-IR and mass spectrometry of lupeol (1), a mixture of the steroids campesterol (2), b-sitosterol (3) and stigmasterol (4), sesamin (5), trans-dimethylmatairesinol (6), trans-methylpluviatolide (7), quercetin (8), and d-mannitol (9) isolated from wood of Zanthoxylum rigidum. The lignans 5, 6 and 7 were tested for their ability to inhibit the proliferation of the promastigote forms of Leishmania braziliensis and Leishmania chagasi. Only sesamin (5) and trans-methylpluviatolide (7) showed moderate inhibitory activity with IC50 = 22.4 and 33.6, SI = 3.87 and 2.41 and CC50 = 86.9 and 81.2, for L. braziliensis and L. chagasi, respectively, compared to the positive control (amphotericin B).
ISSN:2231-0894
2231-0894
DOI:10.9734/ejmp/2021/v32i530390