Immunohistochemical Expression of Clustered Differentiation 10 (CD10) Across Various Grade & Stage of Urinary BladderCarcinoma

• Published in: Esculapio (Lahore) Vol. 19; no. 2; pp. 231 - 235
• Main Authors: Shoukat, Sidra, Nabi, Uzma, Begum, Atiya, Sarwar, Afia, Sadiq, Sara, Irfan, Fakhar
• Format: Journal Article
• Language: English
• Published: 19.08.2023
• ISSN: 2309-3080
• DOI: 10.51273/esc23.2519219

Objective: To assess the Clustered Differentiation 10 (CD10) expression in Urothelial carcinoma and to ascertain how its expression relates to grade and stage. Method: Descriptive cross sectional research was carried out over a period of six months in Pathology Department on eighty five cases of bladder carcinoma from transurethral resection of bladder (TURBT) specimens diagnosed on Hematoxylin-eosin (H & E) stained sections irrespective of patient's age and gender were included in the study. These were stained for CD10 by Immunohistochemical technique. Results: Sixty seven (78.8%) urothelial carcinomas showed positive CD10 staining while 18 cases (21.17%) demonstrated negative expression. In 67 positive cases, 42 high grade tumors had 2+ expression while 13 grade had 1+ staining .All low-grade tumors(12) displayed 1+ score. Sixteen tumorsin pT1, 21 tumorsin pT2 and 3 tumors in pT3 stage displayed 2+ score. Nineteen tumors in pT1 while 4 tumors in pT2 had 1+ score. Conclusion: Our findings indicate that CD10 expression is greater in high grade and invasive urothelial carcinomas and is associated with progression of bladder carcinomas.