Lidocaine improves psoriasis by calming down inflammatory cells
Abstract Psoriasis is an incurable chronic skin disease. In addition to immune system participation, cutaneous nervous system has long been reported to play a role in psoriasis pathogenesis. However, the clinical application and underlying mechanism of how peripheral sensory nervous system works dur...
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Published in | The Journal of immunology (1950) Vol. 204; no. 1_Supplement; pp. 238 - 238.22 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
01.05.2020
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Online Access | Get full text |
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Summary: | Abstract
Psoriasis is an incurable chronic skin disease. In addition to immune system participation, cutaneous nervous system has long been reported to play a role in psoriasis pathogenesis. However, the clinical application and underlying mechanism of how peripheral sensory nervous system works during psoriasis pathogenesis are largely unknown. Here we report a new and straight-forward clinical strategy using epidural injection of lidocaine to directly manipulate peripheral sensory nervous system, resulting in significant PASI score improvement of psoriasis patients. Imiquimod-induced rat model of psoriasis shows consistent therapeutic effect with epidural injection of lidocaine. Transcriptome analysis of lidocaine-treated rat primary sensory neurons indicates that lidocaine may function through calming down neuronal proinflammatory chemokines (CCL2, CCL7 and CCL21), cytokines (IL-34 and TSLP). Collectively, our results reveal that direct modulation of peripheral sensory nervous system by epidural treatment with lidocaine reveals a novel and promising therapy for psoriasis treatment. |
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ISSN: | 0022-1767 1550-6606 |
DOI: | 10.4049/jimmunol.204.Supp.238.22 |