Fluvastatin suppresses IgE-mediated mast cell activation in vitro and in vivo (HYP3P.411)

Abstract Fluvastatin, the HMG-CoA reductase inhibitor known for its role in the treatment of hypercholesterolemia and cardiovascular disease, has more recently been shown to play a role in the immune response. Given the critical role that mast cells play in allergy and inflammatory diseases such as...

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Bibliographic Details
Published inThe Journal of immunology (1950) Vol. 192; no. 1_Supplement; pp. 54 - 54.23
Main Authors Kolawole, Elizabeth, Ndaw, Victor, Ryan, John
Format Journal Article
LanguageEnglish
Published 01.05.2014
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Summary:Abstract Fluvastatin, the HMG-CoA reductase inhibitor known for its role in the treatment of hypercholesterolemia and cardiovascular disease, has more recently been shown to play a role in the immune response. Given the critical role that mast cells play in allergy and inflammatory diseases such as asthma, which effects one third of America’s population, we assessed the effect of Fluvastatin on mast cell function. We demonstrate that Fluvastatin downregulated IgE-mediated cytokine production and mast cell migration. Additionally, in vivo studies showed that Fluvastatin suppressed IgE-mediated anaphylaxis. Interestingly, the effect of Fluvastatin may be restricted to mast cells cultured from mice with a Th1-prone background. Characterizing the role of Fluvastatin on mast cells may prove to be therapeutically important.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.192.Supp.54.23