Collagen gene polymorphisms relative to stress urinary incontinence / Associação entre polimorfismos do gene do colágeno e Incontinência urinária de esforço

• Published in: Brazilian Journal of Development Vol. 8; no. 4; pp. 26536 - 26544
• Main Authors: Pinheiro, Ana Maria Pearce de Arêa Leão, Do Monte, Semiramis Jamil Hadad, Da Silva, Adalberto Socorro, Neto, José Machado Moita
• Format: Journal Article
• Language: English
• Published: 13.04.2022
• ISSN: 2525-8761; 2525-8761
• DOI: 10.34117/bjdv8n4-251

Objective: To investigate the possible association between the single-nucleotide polymorphism G→T at the Sp1-binding site at the first intron of the COLIA1 gene and Stress Urinary Incontinence. Study design: We compared the allelic and genotypic frequencies of the COLIA1 gene in patients with SUI (n=29) to those with healthy individuals (n=22). Our strategy was the amplification and the restriction fragment length polymorphism of a DNA fragment with Sp1-binding at the first intron of COLIA1 gene. The results were statistically assessed by Fisher and Mann Whitney’s tests. Results: There were no significant differences between the allelic and genotypic frequencies of COLIA1 gene when comparing individuals with SUI to healthy ones (p=1). Conclusion: The results showed no association between the G→T single-nucleotide polymorphism at the Sp1 binding site at the first intron of the COLIA1 gene and Stress Urinary Incontinence.