Comparison of the effects of aqueous extract of Sida cordifolia L. and 5-fluorouracil in colon carcinogenesis induced by 1,2- dimethylhydrazine on Wistar rats

Search for new therapeutic agents and alternative strategies for chemoprevention of colorectal cancer is needed to reduce morbidity and mortality resulting from this disease. This study aimed to compare the effect of aqueous extract of Sida cordifolia L. and 5- fluorouracil (5-FU) on colon carcinoge...

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Published inRevista Fitos Vol. 16; no. 2; pp. 169 - 180
Main Authors Cruz, Filipe Jonas Federico da, Souza, Daniel Ferreira Almeida de, Anjos, Samila Fernandes dos Santos, Barbosa, Ana Paula Fernandes, Marques, Juliana Pedrosa de Holanda, Barros, Svetlana Maria Wanderley de, Santana, Antonio Euzebio Goulart, Moreira, Magna Suzana Alexandre, Jucá, Mario Jorge
Format Journal Article
LanguageEnglish
Published 30.06.2022
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Summary:Search for new therapeutic agents and alternative strategies for chemoprevention of colorectal cancer is needed to reduce morbidity and mortality resulting from this disease. This study aimed to compare the effect of aqueous extract of Sida cordifolia L. and 5- fluorouracil (5-FU) on colon carcinogenesis induced by 1,2- dimethylhydrazine (1,2-DMH). The extract reduced the frequency of aberrant crypts to regarding the positive control, but there was no significant difference among the positive control animals, those who received the extract and those receiving standard anticancer drug. Thus, the aqueous extract of Sida cordifolia L. 800 mg/kg showed no statistical impact on carcinogenesis in animal models, but showed a significant anti-inflammatory effect on the colon mucosa.
ISSN:1808-9569
2446-4775
DOI:10.32712/2446-4775.2022.1085