THE FORMULATION OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM OF ETHANOL EXTRACT OF Marsilea crenata C. Presl. LEAVES

• Published in: Rasāyan journal of chemistry Vol. 16; no. 2; pp. 934 - 943
• Main Authors: B. Ma’arif, Y. Tamara, Al-Azzam, F. A. S, R. Azzahara, F. Rizki, H. Sugihantoro, N. Maulina, M. Agil
• Format: Journal Article
• Language: English
• Published: 2023
• ISSN: 0974-1496; 0974-1496
• DOI: 10.31788/RJC.2023.1628342

Marsilea crenata C. Presl. contains phytoestrogens, which have structures or activity similar to estrogen and could potentially be utilized as a neuroprotector in an estrogen deficiency disease. This study aims to utilize M. crenata in the formulation of SNEDDS as a neuroprotector. The dosage form chosen aims to maintain stability and effectiveness because of its multi-compound properties. M. crenata was extracted using ethanol, then formulated into four SNEDDS formulas, and then characterization was done, which included physical quality (organoleptic and pH), particle size, polydispersity index, transmittance percentage, and Scanning Electron Microscope (SEM) analysis. The results showed that the four formulas produced a homogenous yellow color with a distinctive odor formulation; the values of the pH, particle size, polydispersity index, and transmittance percentage were still in the allowable range; and the SEM analysis showed that SNEDDS particles dominated with a spherical shape of particles. It can be concluded that the ethanol extract of M. crenata leaves can be formulated into SNEDDS and the best SNEDDS formulation was formula B at 100 ppm extract concentration which had the smallest particle size, smallest polydispersity index, and the largest transmission percentage.