Урахування гіперурикемії, подагри та гендерних нозологічних особливостей в діяльності лікаря загальної практики – сімейної медицини

• Published in: Likarska sprava no. 5; pp. 44 - 57
• Main Author: Rudichenko, V. M.
• Format: Journal Article
• Language: English
• Published: 28.08.2012
• ISSN: 1019-5297; 2706-8803
• DOI: 10.31640/LS-2012-5-05

In this article there were analyzed gender data about features of hyperuricaemia and gout: women are much older at the onset of gout arthritis (one of main reasons, probably, makes menopause by itself), have more associated comorbid deseases as hypertension and kidney failure and drinks less alcoholic beverages. It was noticed, that typical localisation of the lesion on the first toe is less often in women, and women are more inclined to use diuretics among medical drugs. Abovementioned clinical features are of some importance for the broad activity of general practitioners – family doctors. Gender features of polyarthicular gout are not uniformed. Scientific researches confirmed possibility of the genetic basis of the uric acid metabolism, which influences some fenotypical features of the organism. Several genes are known for their influence on serum uric acid: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9 аnd SLC22A12. However, conclusions of the research works confirm the necessity of scientific clarification of the importance of different factors of gender differences.