Topical Zinc May Augment Post-Operative Wound Healing, Including Following Mohs Micrographic Surgery: A Review of the Literature

• Published in: Skin (Milwood, N.Y.) Vol. 4; no. 5; pp. 395 - 403
• Main Authors: Levin, Nicole, Gray, Taylor, Farsi, Maheera, Dorton, David, Miller, Richard
• Format: Journal Article
• Language: English
• Published: 01.09.2020
• ISSN: 2574-1624; 2574-1624
• DOI: 10.25251/skin.4.5.1

Background: Zinc, an essential mineral, has been extensively studied in the field of dermatology for the treatment of a plethora of skin conditions. However, minimal literature exists regarding its use for the enhanced healing of wounds after surgery, including following Mohs micrographic surgery (MMS).Objective: Evaluate the available literature regarding the utilization of zinc for enhanced healing of post-surgical wounds in humans.Methods: A systematic review of studies evaluating the use of zinc for post-surgical management was conducted via an electronic literature search of the PubMed database. Clinical trials were searched using ClinicalTrails.gov.Results: Topical zinc formulations may decrease healing time and post-operative infection rates, including following MMS of the lower extremity.Limitations: Currently, there are a limited number of studies available on this topic, with lack of a standard comparable outcome measure.Conclusion: Topical zinc oxide may be a beneficial treatment option for post-surgical wound healing, including after MMS. Further studies are needed to better define the efficacy of zinc for post-operative wound healing and the optimal treatment regimen.