1602-P: Delayed Insulin Secretion in Early Postpartum Is Associated with Future Abnormal Glucose Metabolism among Women with a History of Gestational Diabetes Mellitus

• Published in: Diabetes (New York, N.Y.) Vol. 74; no. Supplement_1
• Main Authors: LIANG, SHUHUI, XU, CHANGLIU, LAI, FENGHUA, LI, YANBING, CAO, XIAOPEI
• Format: Journal Article
• Language: English
• Published: 20.06.2025
• ISSN: 0012-1797
• DOI: 10.2337/db25-1602-P

Introduction and Objective: The present study aims to determine the relationship between insulin secretion pattern after glucose load in the early postpartum period (< 6 months) and the incidence of abnormal glucose metabolism (AGM) in the future among women with a history of gestational diabetes mellitus (GDM). Methods: This is a prospective cohort study that conducted survival analysis on the medical records of 308 women with prior GDM. All eligible subjects underwent a 75g oral glucose tolerance test (OGTT) within 6 months postpartum and insulin levels were measured before, 30 minutes and 2 hours after glucose load..Participants were divided into two groups: delayed insulin secretion group: 2h insulin levels ≥ 30min insulin levels (In 2h ≥ In 30min) (n=196), and control group (In2h < In30min) (n=112). Multiple imputation was used to handle missing values. Results: Of the 308 women, 153 occurred AGM (49.7%) within a mean follow-up time of 32.7 months. Women in In2h ≥ In30min group had a 52.5% increased risk of developing AGM (adjusted hazard ratio [HR] 1.525 [95% CI 1.044-2.227], P=0.029). Other risk factors included: fasting blood glucose during pregnancy, triglycerides and AGM within 6 months postpartum (adjusted HR 1.580 [95% CI 1.232-2.027], 1.395 [95% CI 1.048-1.855], and 1.559 [95% CI 1.045-2.337], respectively, all P<0.05) Conclusion: In women with a history of GDM, delayed insulin secretion after glucose load within 6 months postpartum were associated with an increased incidence of future AGM.