COMPARISON OF 1% CHLOROPROCAINE IN SUB-ARACHNOID BLOCK WITH OR WITHOUT FENTANYL FOR ENHANCED RECOVERY AFTER PERIANAL SURGERIES

• Published in: Asian journal of pharmaceutical and clinical research pp. 131 - 134
• Main Authors: Tripat Kaur Bindra, Davinder Chawla, Ashwani Kumar, Gurlivleen Kaur, Amit Kaur
• Format: Journal Article
• Language: English
• Published: 07.07.2022
• ISSN: 0974-2441; 0974-2441
• DOI: 10.22159/ajpcr.2022.v15i7.44841

Objective: Spinal anesthesia is a reliable and safe technique for procedures of lower abdomen, perianal surgeries, and lower limbs. The current availability of short acting local anesthetic agents like preservative free 1% chloroprocaine has renewed the interest for this technique in short- and ultra-short procedures. Opioids continue to be the most commonly added adjuvants in local anesthetics for potentiation of analgesic action. In this study, we investigated the effect of intrathecal fentanyl as an adjuvant to 1% chloroprocaine in patients undergoing perianal surgeries. Methods: This prospective, randomized, and comparative study was conducted in 80 ASA Physical status I and II adult patients (age 20–80 years) undergoing perianal surgeries under spinal anesthesia. Group A patients received 1% chloroprocaine 3 ml (30 mg) and 0.4ml saline and Group B patients received 1% chloroprocaine 3 ml (30 mg) with fentanyl 0.4 ml (20 μg). Primary objectives were duration of analgesia and time to unassisted ambulation. Onset and duration of sensory and motor blockade, maximum height of sensory block, 2 segment regression, hemodynamic parameters, time to voiding, home discharge eligibility, and any side effects were also recorded. Results: There were no significant differences in demographic characteristics and hemodynamic parameters. The duration of sensory block and duration of analgesia were statistically prolonged in Group B than Group A (p<0.001) without affecting recovery from motor block and time to unassisted ambulation. The adverse effects were comparable in both the groups. Conclusion: The addition of fentanyl to 1% chloroprocaine intrathecally prolonged the duration of analgesia and sensory block in patients undergoing perianal surgeries.