SEX DIFFERENCES OF ENDOTHELIAL DYSFUNCTION MARKERS — NITRIC OXIDE SYNTHASE AND HEME OXYGENASE IN RATS WITH 2 TYPE DIABETES MELLITUS

• Published in: Problems of Endocrine Pathology Vol. 66; no. 4; pp. 37 - 43
• Main Authors: Borikov, Oleksii, Gorbenko, Nataliia, Ivanova, Olha, Taran, K. V., Litvinova, T. S., Kiprich, Tetiana
• Format: Journal Article
• Language: English
• Published: 03.12.2018
• ISSN: 2227-4782; 2518-1432
• DOI: 10.21856/j-PEP.2018.4.04

The effect of type 2 diabetes on the markers of endothelial dysfunction — nitric oxide synthase and heme oxygenase has been studied in rats, depending on sex. It was established that the activity of nitric oxide synthase in the blood vessels of female rats is significantly higher in comparison with males under physiological conditions. Type 2 diabetes leads to the different depression of the nitric oxide synthase activity in the blood vessels of females and males, which eliminates sexual differences in the activity of this enzyme. It was found that in contrast to nitric oxide synthase, the activity of heme oxygenase in vascular homogenate does not depend on the sex of intact animals. Type 2 diabetes leads to more expressive increase in heme oxygenase activity in female blood vessels compared to male rats. We can suppose that a more pronounced elevation of the heme oxygenase activity in case of a decrease the nitric oxide synthase activity is a compensatory mechanism for reducing of endothelial dysfunction in women with type 2 diabetes.