A comparative study for antinociceptive potential of vitamin D3 with diclofenac in animal models

• Published in: International journal of basic and clinical pharmacology Vol. 6; no. 3; p. 608
• Main Authors: David, Abhinav, Goel, Raj Kumar, Patel, Prashant, Paul, Priyadarshani
• Format: Journal Article
• Language: English
• Published: 24.02.2017
• ISSN: 2319-2003; 2279-0780
• DOI: 10.18203/2319-2003.ijbcp20170822

Background: Calcitriol is one of the active forms of vitamin D. It not only acts on calcium metabolism but might have a role in treating various disorders also through vitamin D receptors that are present in many tissues besides intestine and bone. This study was conducted to compare antinociceptive activity of Calcitriol with Diclofenac and Morphine in animal models.Methods: In this study, healthy Swiss albino mice were taken after permission from IAEC. Mice were divided into six groups as one control- treated with normal saline, two standards - treated with diclofenac and treated with morphine while three tests - treated with Calcitriol in dose of 15µg /kg/mice, 30µg/kg/mice and 60µg/kg/mice respectively. Comparison of antinociception was done using Tail pinch and writhing method.Results: Tail pinch and Writhing methods were used for comparison of antinociceptive activity. In tail pinch model, Calcitriol showed some analgesia at 30 and 60μg/Kg doses, which was more than control but not comparable with the standard Morphine. In writhing method, test doses of Calcitriol (15 and 30μg/Kg) failed to show analgesic efficacy in inflammatory pain but test dose of 60μg/Kg showed some analgesic activity which was not comparable with standard Diclofenac.Conclusions: Antinociception was exhibited at higher doses of Calcitriol by tail pinch method while in writhing method analgesic activity was shown with only 60 μg/Kg dose of Calcitriol. The results obtained from this study needs to be further evaluated by planning extensive animal experimentation.