Synthesis and Antimicrobial Screening of 2"-Amino-4"-[2-(4'-Chlorophenyl)-6-Methyl Imidazo[1, 2-a]Pyridine -3-yl]-6"-Aryl-4"-H-Pyran-3"-Carbonitrile

3-Cyano-4,6-disubstituted 4H-pyrans are endowed with a variety of pharmacodynamic activities Looking to the interesting properties of cyanopyrans, it was considered worthwhile to synthesis some new 2"-amino-4"-[2-(4'-chlorophenyl) -6-methyl imidazo [1,2-a] pyridin-3-yl]-6"-aryl-4...

Full description

Saved in:
Bibliographic Details
Published inInternational letters of chemistry, physics and astronomy Vol. 49; pp. 149 - 154
Main Authors Bhuva, V.V., Bhadani, V.N., Purohit, H.D., Purohit, Dipak M.
Format Journal Article
LanguageEnglish
Published 01.04.2015
Online AccessGet full text

Cover

More Information
Summary:3-Cyano-4,6-disubstituted 4H-pyrans are endowed with a variety of pharmacodynamic activities Looking to the interesting properties of cyanopyrans, it was considered worthwhile to synthesis some new 2"-amino-4"-[2-(4'-chlorophenyl) -6-methyl imidazo [1,2-a] pyridin-3-yl]-6"-aryl-4"-H-pyran-3"- carbonitrile ( 4a-4l ) have been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram –ve bacteria and fungi. Some of the products showed moderate activity in concentration 50μg/mL. The structures of the products have been elucidated by IR, 1 H-NMR, Mass spectral data, elemental analysis and thin layer chromatography. Keyw ords : Cyanopyrans; antibacterial activity; antifungal activity
ISSN:2299-3843
2299-3843
DOI:10.18052/www.scipress.com/ILCPA.49.149