Effect of revascularization of coronary arteries on mechanical dyssynchrony of left ventricular myocardium in patients with coronary heart disease

• Published in: Shidnoevropejskij zurnal vnutrisnoi ta simejnoi medicini Vol. 2024; no. 1; pp. 57 - 62
• Main Authors: Mehtieva, Fatma, Bilchenko, O.V.
• Format: Journal Article
• Language: English
• Published: 01.07.2024
• ISSN: 2411-1457; 2415-346X
• DOI: 10.15407/internalmed2024.01.057

Introduction. Defining a treatment strategy for patients with stable coronary heart disease will require the development of personalized criteria, among which the assessment of myocardial dyssynchrony is considered promising. The aim of the study was to evaluate the effect of revascularization of coronary arteries on indicators of mechanical myocardial dyssynchrony in patients with stable coronary heart disease. Materials and methods. The study included 121 patients with coronary heart disease, who were assessed for mechanical myocardial dyssynchrony before and 2 weeks after revascularization. The main group included 48 patients with myocardial dyssynchrony, and the comparison group included 73 patients without myocardial dyssynchrony. Complete occlusion and lesions of 3 coronary arteries were found more often in the group with myocardial dyssynchrony, and the main group also had a higher SYNTAX SCORE. The results. Mechanical dyssynchrony of the myocardium was found in 39% of patients with coronary heart disease. Before revascularization, a signifiant increase in SPWMD, APEI, IVMD, and a decrease in LVFT and LVET were found in the group of patients with myocardial dyssynchrony. After revascularization in the main group, in 9 patients out of 48 (18.7%), indicators of myocardial dyssynchrony returned to normal values. LVFT in the group of patients with myocardial dyssynchrony significantly increased, as well as left ventricular ejection time (LVET) (from 318.5±9.6 ms to 344.9±23.2 ms, p<0.01). Conclusions. After revascularization, the number of patients with myocardial dyssynchrony significantly decreased due to the improvement of interventricular and intraventricular dyssynchrony indicators. Key words: myocardial dyssynchrony, coronary heart disease, revascularization, coronary angiography, SYNTAX SCORE.