Copper (II) complexes with some antibiotics: synthesis, FT-IR study and in vitro antibacterial activity

Copper (II) complexes with commercial antibiotics, amoxicillin (AMX), azithromycin (AZT) and ciprofloxacin (CFL) were synthesized and isolated as solids. Structures of the isolated products were determined by FTIR spectroscopy. Antibacterial activities were determined on reference bacterial strains...

Full description

Saved in:
Bibliographic Details
Published inInternational Journal of Advanced Chemistry Vol. 11; no. 1; pp. 10 - 14
Main Authors Cipurković, Amira, Marić, Snježana, Horozić, Emir, Husejnagić, Darja, Cipurković, Suada
Format Journal Article
LanguageEnglish
Published 02.03.2023
Online AccessGet full text

Cover

More Information
Summary:Copper (II) complexes with commercial antibiotics, amoxicillin (AMX), azithromycin (AZT) and ciprofloxacin (CFL) were synthesized and isolated as solids. Structures of the isolated products were determined by FTIR spectroscopy. Antibacterial activities were determined on reference bacterial strains from the ATCC collection by diffusion technique. The results show that AMX and CFL coordinate Cu (II) ion as bidentate O-donor ligand. AZT coordinates metal center as bidentate NO-donor ligand. A difference in the morphology of antibiotic crystals and the synthesized complexes was found. Complex of Cu (AMX)2 show complete absence of antibacterial activity, while the other com-plexes show the same or even lower activity than the parent ligands.  
ISSN:2310-2977
2310-2977
DOI:10.14419/ijac.v11i1.32251