Relation assessment between TAN and AR with the survival of breast cancer patients

• Published in: Journal of clinical oncology Vol. 41; no. 16_suppl; p. e12542
• Main Authors: Moghimi, Minoosh, Tavakkolian, Pouria, Ahmadi, Farzane, Mansouri, Reza, Khodadadi, Kasra
• Format: Journal Article
• Language: English
• Published: 01.06.2023
• ISSN: 0732-183X; 1527-7755
• DOI: 10.1200/JCO.2023.41.16_suppl.e12542

e12542 Background: Considering the importance of the relationship between biomarkers and survival in breast cancer patients, finding this relationship can play a key role in understanding disease behavior, determining prognosis and even identifying targeted treatments. This study was conducted with the aim of investigating the relationship between TAN (Tumor associated neutrophil) and AR (Androgen receptor) with survival in patients with breast cancer. Methods: In this cohort study, 83 female patients with stage I- IV breast cancer were included. we investigated the relationship between TAN and AR with the three-year survival time. Patients were diagnosed between April 2018 and March 2021. Also, the latest follow-up was performed in December 2022. The Cox-hazard model was used to determine the factors influencing the survival time of patients. Results: Out of 83, follow-up was conducted for 81 women. The mean±SD age of diagnosis was 49.5±11.1 years. Sixteen (19.75%) of them died and the mean (95% C.I) for follow-up time was 32.78 (30.97-34.58) months. The one, two, and three survival rates were 0.95, 0.89, and 0.80, respectively. The mean survival time (month) for AR-TAN-, AR+TAN-, AR+TAN+, and AR-TAN+ was 35.75, 33.50, 32.36, and 28.58 respectively. The 3-year survival in the AR-TAN-, AR+TAN-, AR+TAN+ and AR-TAN+ groups was 0.88, 0.88, 0.79, and 0.50, respectively. Conclusions: AR positivity and TAN negativity are in favor of better three-year overall survival regardless of subtypes, however the differences were not statistically significant. The Survival status was significantly lower in the AR-TAN+ group compared to AR + TAN- group. These results are a promising way to the future studies. [Table: see text]