Abstract P311: The Association Of Locomotive Syndrome/low Bone Mineral Density And Increased Arterial Stiffness

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 80; no. Suppl_1
• Main Authors: Matsumoto, Chisa, Tomiyama, Hirofumi, Nakano, Hiroki, Matsuura, Mari, Shiina, Kazuki, Yamashina, Akira
• Format: Journal Article
• Language: English
• Published: 01.09.2023
• ISSN: 0194-911X; 1524-4563
• DOI: 10.1161/hyp.80.suppl_1.P311

Abstract only Background: Both frailty and osteoporosis have been regarded as risk factors of cardiovascular disease (CVD). However, it has not been reported whether the combination of osteoporosis and frailty is associated with arterial stiffness, a marker for CVD. The objective of this study is to evaluate the association of and arterial stiffness. Hypothesis: We hypothesized combination of frailty and osteoporosis is associated with increased arterial stiffness. Methods: Japanese Subjects above 50 years old who underwent annual health-checkup were enrolled in this cross-sectional study. Subjects with history of CVD and dementia were excluded. Arterial stiffness was evaluated by brachial-ankle pulse wave velocity (baPWV). Forearm bone mineral density (BMD) was measured by dual energy X-ray absorptiometry and young adult mean (YAM) less than 80% was defined as low bone mineral density (LB). We evaluated frailty by screening Locomotive syndrome (LS) assessed by the questionnaires (GLFS-25) and physical performance tests consisted of those for a two-step test and a stand-up test according to the guidance of the Japanese Orthopedic Association. The association of combination of LS and LB, LS, LB and baPWV was assessed by multivariable linear regression analysis adjusted for conventional CVD risk factors. Results: Among 137 subjects (mean age: 59±6 years), 7 subjects (20%) had both LS and LB. The numbers of subjects who had only LS, only LB, and none of those were, 58, 10, 62, respectively. BaPWV in subjects with combination of LS and LB was highest compared to subjects with only sarcopenia, only obesity, and none of those (Figure, p=0.01). Multivariable linear regression analysis revealed that the combination of LS and LB, LS, LB, were gradually associated with increased arterial stiffness even after adjustment for conventional CVD risk factors. (β=57±21, p<0.01). Conclusion: The combination of LA and LB was significantly associated with increased arterial stiffness. Further research on frailty/osteoporosis and arterial stiffness is warranted.