Abstract 11897: Prevalence of Abnormalities of Mineral Metabolism in Patients With Stable Coronary Artery Disease According to Renal Function

• Published in: Circulation (New York, N.Y.) Vol. 144; no. Suppl_1
• Main Authors: Gaebelt, Hans P, Martinez-milla, Juan, Pello, Ana M, Lopez-Castillo, Marta, Acena, Alvaro, Cristobal, Carmen, Nieves, Tarin, Huelmos, Ana, Gonzalez Casaus, Maria L, Gutierrez Landaluce, Carlos, lorenzo, oscar, Canovas, Ester, Kallmeyer, Andrea, Alonso, Joaquin, tunon, Jose
• Format: Journal Article
• Language: English
• Published: 16.11.2021
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.144.suppl_1.11897

Abstract only Background: Disturbances of mineral metabolism (MM) are present in pts. with stable coronary artery disease (SCAD) and average renal function. However, differences in these abnormalities in pts. with or without renal disease have not been reported previously. Purpose To describe the differences in MM markers (phosphate, calcidiol, parathormone [PTH], fibroblast growth factor23 [FGF23] and klotho) in patients with SCAD and estimated glomerular filtration rate (eGFR)<60 ml/min/1.73 m2 (LGFR) vs pts. with eGFR≥60 ml/min/1.73 m2 (HGFR). Methods: We analyzed MM parameters in 964 patients with SCAD in five hospitals of Spain. Patients were divided in two subgroups: LGFR and HGFR. Total death was assessed during follow-up. eGFR was calculated by the Chronic Kidney Disease Epidemiology Collaboration equation. Results: There were 790 pts. with HGFR and 174 with LGFR. Pts with LGFR were older and had more incidence of hypertension, diabetes, peripheral artery disease, history of cerebrovascular attack and prior coronary artery by-pass graft than those with HGFR. Left ventricular ejection fraction<40%, and previous diagnoses of heart failure, and atrial fibrillation were also more common in LGFR pts. Phosphate, FGF23 and PTH plasma levels were higher in LFGR pts., while klotho levels were lower in this subgroup. Calcidiol plasma levels did not show significant differences between both subgroups. During follow-up (median 5.1 years), death by any cause was more frequent in patients with LGFR vs HGFR (17.2% vs 5.7%, respectively; p<0.001). Conclusion: Pts. with SCAD and eGFR<60 ml/min/1.73 m2 show lower klotho plasma levels, higher levels of phosphate, FGF23, and PTH, and increased mortality than those with eGFR≥60 ml/min/1.73 m2.