Abstract 18413: Systolic Circumferential Strain Derived From Feature-Tracking Cardiovascular Magnetic Resonance Predicts Survival After Cardiac Resynchronization Therapy

• Published in: Circulation (New York, N.Y.) Vol. 128; no. suppl_22
• Main Authors: Taylor, Robin J, umar, Fraz, Lin, Lai S, Ahmed, Amar, Steeds, Rick P, Leyva, Francisco
• Format: Journal Article
• Language: English
• Published: 26.11.2013
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.128.suppl_22.A18413

Abstract only Objective: The clinical outcome of cardiac resynchronization therapy (CRT) is variable. Feature-tracking cardiovascular magnetic resonance (FT-CMR) allows quantification of myocardial strain using a routine CMR scan. We hypothesized that pre-implant peak systolic circumferential strain (Ecc) predicts survival after CRT. Methods: In this prospective study, 98 patients (age: 66 ± 12 yrs, LVEF: 24 ±11%, QRS: 145 ± 30ms) had pre-implant assessment of peak systolic Ecc from the mid cavity LV short-axis slice. This measure, which involved 1.2 ± 0.3 min of post-processing, was assessed in relation to all cause mortality. Results: The mean peak systolic Ecc was 7.5 ± 5.0% amongst the entire cohort. 30 patients died over a follow-up of 3.9 ± 2.4 yrs (mean ± SD). Above an optimum cut-off of 10%, Ecc, predicted survival after CRT (Chi-squared: 5.37, log-rank p = 0.01; area under the receiver-operator characteristic curve: 0.67, 95% CI 0.58 - 0.79, p = 0.003). Conclusion: The rapid assessment of pre-implant peak systolic Ecc derived from FT-CMR predicts survival after CRT.