Abstract 2952: Generation and molecular profiling of drug-resistant cancer cell lines

• Published in: Cancer research (Chicago, Ill.) Vol. 76; no. 14_Supplement; p. 2952
• Main Authors: He, Fang, Pan, Pengwei, Yuan, Zengjin, Huang, Jingqi
• Format: Journal Article
• Language: English
• Published: 15.07.2016
• ISSN: 0008-5472; 1538-7445
• DOI: 10.1158/1538-7445.AM2016-2952

Abstract Drug resistance is the main cause of ineffective chemotherapy in patients. Many cancers respond initially well to therapy but eventually the cancer recurs as drug-resistant disease leading to the patient death. Therefore, a better understanding of the molecular basis of the drug resistance is warranted in order to elucidate the mechanisms and markers underlying this drug-resistant phenotype In this study, we aimed to generate and characterize a panel of drug resistant cancer cell lines, providing a valuable tool with which to investigate the molecular pathways and putative markers that may be associated with this resistance phenotype in cancer. Citation Format: Fang He, Pengwei Pan, Zengjin Yuan, Jingqi Huang. Generation and molecular profiling of drug-resistant cancer cell lines. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2952.