Meropenem-resistant Burkholderia pseudomallei: a concerning single case in Australia with no prior meropenem exposure

We report a case of cutaneous melioidosis in a 54-year-old male with a meropenem-resistant sub-population. He was empirically treated with episodic doxycycline and trimethoprim–sulfamethoxazole; however, the abscess re-accumulated. The patient had no prior exposure to meropenem. A sub-population of...

Full description

Saved in:
Bibliographic Details
Published inAccess microbiology Vol. 6; no. 10
Main Authors Sivabalan, Pirathaban, Satyaputra, Ferris, Gassiep, Ian, Forde, Brian, Frazer, Jaimie, Glover, Matthew, Adams, Buenafe, Norton, Robert
Format Journal Article
LanguageEnglish
Published 01.10.2024
Online AccessGet full text

Cover

More Information
Summary:We report a case of cutaneous melioidosis in a 54-year-old male with a meropenem-resistant sub-population. He was empirically treated with episodic doxycycline and trimethoprim–sulfamethoxazole; however, the abscess re-accumulated. The patient had no prior exposure to meropenem. A sub-population of the isolate was meropenem resistant with an MIC >32 µg ml −1 and the identification was re-confirmed as Burkholderia pseudomallei . Whole-genome sequencing with ARDaP analysis only revealed a resistance determinant to doxycycline and did not reveal a resistance determinant to meropenem. Furthermore, no carbapenemases were detected through multiple bioinformatics tools. To date, this is the first reported case in Australia of a B. pseudomallei isolate resistant to meropenem without previous carbapenem exposure.
ISSN:2516-8290
2516-8290
DOI:10.1099/acmi.0.000619.v4