P-279 ADVANCED MATERIALS AND THEIR POSSIBLE USE FOR INFECTIOUS RISK MITIGATION IN HEALTHCARE SETTING

• Published in: Occupational medicine (Oxford) Vol. 74; no. Supplement_1
• Main Authors: Tomao, Paola, Mansi, Antonella, Marcelloni, Anna Maria, Chiominto, Alessandra, Bertani, Roberta, Zappalorto, Michele
• Format: Journal Article
• Language: English
• Published: 05.07.2024
• ISSN: 0962-7480; 1471-8405
• DOI: 10.1093/occmed/kqae023.0851

Abstract Introduction Hospital surfaces play an important role in the transmission of pathogens responsible for healthcare-associated infections (HAIs). In addition to patients, although less frequently, doctors, nurses and other health professionals may also be affected by these infections. The aim of this study is to assess the antibacterial activity of new epoxy resin-based materials (NM1 and NM2) for their possible use as collective protection measures in healthcare settings. Methods To evaluate the in vitro bactericidal activity of NM1 and NM2, the tests were carried out according to ISO 22196:2011. Known concentrations of E. coli ATCC® 8739 and S. aureus ATCC® 6538P were deposited on NM samples. Bactericidal activity was evaluated by calculating the average reduction (R) of the colony forming units (CFU) per cm2 in NM samples compared to controls. Results The results show that the NM1 is effective (R=2.36 Log CFU/cm2) against E. coli but not against S. aureus. As for the NM2, this has bactericidal activity both against E. coli (R=6.68 Log CFU/cm2) and against S. aureus (R=3.75 Log CFU/cm2). Discussion Our preliminary data are extremely promising, particularly those obtained from NM2 tests. Other experimental assays are currently underway on bacteria (Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter Baumanii) responsible for nosocomial infections. Conclusion Several pathogens can persist on hospital surfaces for a long time causing serious infections and epidemic outbreaks. The research in the field of advanced materials could make a significant contribution to the fight against HAIs also limiting the spread of multidrug resistant bacteria.