MO604DIFFERENCES IN THE EXTRACELLULAR BODY WATER/TOTAL BODY WATER (EBW/TBW) IN HEMODIALYSIS AND CHRONIC KIDNEY DISEASE PATIENTS. RELATIONSHIP WITH NUTRITIONAL PARAMETERS

• Published in: Nephrology, dialysis, transplantation Vol. 36; no. Supplement_1
• Main Authors: Barril, Guillermina, Nogueira, Ángel, Alvarez, Graciela, Sapiencia, David, Andres, Natalia, Giorgi, Martin, Nuñez, Almudena, Romasco, Paula
• Format: Journal Article
• Language: English
• Published: 29.05.2021
• ISSN: 0931-0509; 1460-2385
• DOI: 10.1093/ndt/gfab089.0017

Abstract Background and Aims Knowing the hydration status of CKD patients is one of the basic objectives in CKD patients considering the Ratio of EBW(TBW) as indicator of them. Aim Determine the cut-off point of the EBW/TBW ratio using Bioimpedance in patients with global CKD and divided into advanced CKD and hemodialysis (HD) as a hydration marker in relation to MIS scale (malnutrition inflammation score), cut-off point 5. Method We value 199 CKD patients by setting the EBW/TBW cut-off points using Inbody S10 multifrequency bioimpedance with global ROC curve and for advanced CKD (ACKD) and HD analyzing differences according to age ranges (<65,65,1-75 and >75 years) and differences in nutritional parameters (visceral proteins, MIS scale and body composition). Results We have evaluated 199 patients with ACKD, 143 male and 56 female, 74 in CKD xage72.27 ?11.98years and 125 in HD, xage 70.76 ?12.73 years. Overall EBW / TBW ratio: AUC 0.657, p0.006, cut-off point 0.3965 60% sensitivity, 64% specificity. Advanced CKD: AUC 0.648, p0.071, cutoff point 0.397, 64% sensitivity, 61% specificity. HD: AUC 0.706, p0.012, cutoff point 0.391, 71% sensitivity, 63% specificity. The results in relation to age strata and MIS with 5 as the cut-off point in the table. No greater hydration in men than in women overall. The nutrition-inflammation parameters according to the cut-off point are different: Advanced CKD: age 0.001, albumin 0.024, prealbumin 0.013, trasferrin 0.078, CRP 0.432. HD: albumin 0.014, prealbumin 0.001, transferrin 0.939, lymphocytes 0.030, CRP 0.342, age 0.000. Conclusion 1. We have found slightly higher cut-off points between ACKD and hemodialysis in the assessed sample. 2. The EBW / TBW ratio appears higher in patients > 65 years in both ACKD and HD, in contrast to what is observed in the healthy population. 3. A greater malnutrition appairs in a greater hyperhydration in HD and ACKD.