Tandem phospha -Michael addition/cyclization/dehydration of 2-hydroxychalcones with H -phosphine oxides for the synthesis of 4-phosphorylated 4 H -chromenes

A Hg(OTf) 2 -catalyzed tandem phospha -Michael addition/cyclization/dehydration of 2-hydroxychalcones with H -phosphine oxides is presented. This protocol provides a new and supplementary approach for the preparation of 4-phosphorylated 4 H -chromenes in good yields (up to 99%). In addition, this do...

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Published inOrganic & biomolecular chemistry Vol. 21; no. 45; pp. 9076 - 9081
Main Authors Wen, Zhong, Yang, Kai-Cheng, Zheng, Shi-Lu, Zhang, Yu-Shan, Wang, Sheng-Jun, Ni, Hai-Liang, Chen, Long
Format Journal Article
LanguageEnglish
Published 22.11.2023
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Summary:A Hg(OTf) 2 -catalyzed tandem phospha -Michael addition/cyclization/dehydration of 2-hydroxychalcones with H -phosphine oxides is presented. This protocol provides a new and supplementary approach for the preparation of 4-phosphorylated 4 H -chromenes in good yields (up to 99%). In addition, this domino reaction allows the successful construction of two new C–P and C–O bonds in a one-pot operation.
ISSN:1477-0520
1477-0539
DOI:10.1039/D3OB01562A