Simultaneous muscle water T 2 and fat fraction mapping using transverse relaxometry with stimulated echo compensation

• Published in: NMR in biomedicine Vol. 29; no. 4; pp. 431 - 443
• Main Authors: Marty, Benjamin, Baudin, Pierre‐Yves, Reyngoudt, Harmen, Azzabou, Noura, Araujo, Ericky C. A., Carlier, Pierre G., de Sousa, Paulo L.
• Format: Journal Article
• Language: English
• Published: 01.04.2016
• ISSN: 0952-3480; 1099-1492
• DOI: 10.1002/nbm.3459

Skeletal muscle inflammation/necrosis and fat infiltration are strong indicators of disease activity and progression in many neuromuscular disorders. They can be assessed by muscle T 2 relaxometry and water‐fat separation techniques, respectively. In the present work, we exploited differences between water and fat T 1 and T 2 relaxivities by applying a bi‐component extended phase graph (EPG) fitting approach to simultaneously quantify the muscle water T 2 and fat fraction from standard multi‐slice multi‐echo (MSME) acquisitions in the presence of stimulated echoes. Experimental decay curves were adjusted to the theoretical model using either an iterative non‐negative least‐squares (NNLS) procedure or a pattern recognition approach. Twenty‐two patients (age, 49 ± 18 years) were selected to cover a large range of muscle fat infiltration. Four cases of chronic or subchronic juvenile dermatomyositis (age, 8 ± 3 years) were investigated before and 3 months following steroid treatment. For control, five healthy volunteers (age, 25 ± 2 years) were recruited. All subjects underwent the MSME sequence and EPG fitting procedure. The EPG fitting algorithm allowed a precise estimation of water T 2 and fat fraction in diseased muscle, even in the presence of large B 1 + inhomogeneities. In the whole cohort of patients, there was no overall correlation between water T 2 values obtained with the proposed method and the fat fraction estimated inside muscle tissues (R 2 = 0.02). In the patients with dermatomyositis, there was a significant decrease in water T 2 (‐4.09 ± 3.7 ms) consequent to steroid treatment. The pattern recognition approach resulted in a 20‐fold decrease in processing time relative to the iterative NNLS procedure. The fat fraction derived from the EPG fitting approach correlated well with the fat fraction derived from a standard three‐point Dixon method (≈1.5% bias). The bi‐component EPG fitting analysis is a precise tool to monitor muscle tissue disease activity and is able to handle bias introduced by fat infiltration and B 1 + inhomogeneities. Copyright © 2016 John Wiley & Sons, Ltd.