Cover Picture: Oxidative Rearrangement of Isatins with Arylamines Using H 2 O 2 as Oxidant: A Facile Synthesis of Quinazoline‐2,4‐diones and Evaluation of Their Antibacterial Activity (Chin. J. Chem. 12/2017)
The cover picture shows a green and highly efficient synthetic method for the synthesis of quinazoline‐2,4‐diones from readily available isatins and arylamines. This method is interesting in keeping with the notion of green chemistry because of the use of hydrogen peroxide as the terminal oxidant. T...
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| Published in | Chinese journal of chemistry Vol. 35; no. 12; p. 1771 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
01.12.2017
|
| Online Access | Get full text |
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| Summary: | The cover picture shows
a green and highly efficient synthetic method for the synthesis of quinazoline‐2,4‐diones from readily available isatins and arylamines. This method is interesting in keeping with the notion of green chemistry because of the use of hydrogen peroxide as the terminal oxidant. The rearrangement oxidation exhibited good functional group tolerability, metal‐free catalysts, obviating the need for oxidants and only environmentally benign H
2
O was released. Moreover, an antibacterial activity study was performed to evaluate the antimicrobial activities. The results showed that some of the testing compounds inhibited the growth of the
Staphylococcus aureus
(32 μg/mL) and
Staphylococcus epidermidis
(64 μg/mL), which could potentially solve the problem of multidrug resistance. More details are discussed in the article by Shang
et al.
on page 1835–1843.
image |
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| ISSN: | 1001-604X 1614-7065 |
| DOI: | 10.1002/cjoc.201770121 |