Developmental pathways associated with cancer metastasis:Notch, Wnt, and Hedgehog

Master developmental pathways,such as Notch,Wnt,and Hedgehog,are signaling systems that control proliferation,cell death,motility,migration,and stemness.These systems are not only commonly activated in many solid tumors,where they drive or contribute to cancer initiation,but also in primary and meta...

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Published in癌症生物学与医学：英文版 Vol. 14; no. 2
Main Author Armel Herve Nwabo Kamdje Paul Takam Kamga Richard Tagne Simo Lorella Vecchio Paul Faustin Seke Etet Jean Marc Muller Giulio Bassi Erique Lukong Raghuveera Kumar Goel Jeremie Mbo Amvene Mauro Krampera
Format Journal Article
LanguageEnglish
Published 2017
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Summary:Master developmental pathways,such as Notch,Wnt,and Hedgehog,are signaling systems that control proliferation,cell death,motility,migration,and stemness.These systems are not only commonly activated in many solid tumors,where they drive or contribute to cancer initiation,but also in primary and metastatic tumor development.The reactivation of developmental pathways in cancer stroma favors the development of cancer stem cells and allows their maintenance,indicating these signaling pathways as particularly attractive targets for efficient anticancer therapies,especially in advanced primary tumors and metastatic cancers.Metastasis is the worst feature of cancer development.This feature results from a cascade of events emerging from the hijacking of epithelial-mesenchymal transition,angiogenesis,migration,and invasion by transforming cells and is associated with poor survival,drug resistance,and tumor relapse.In the present review,we summarize and discuss experimental data suggesting pivotal roles for developmental pathways in cancer development and metastasis,considering the therapeutic potential.Emerging targeted antimetastatic therapies based on Notch,Wnt,and Hedgehog pathways are also discussed.
Bibliography:Armel Herve Nwabo Kamdje[1];Paul Takam Kamga[2];Richard Tagne Simo[1];Lorella Vecchio[3];Paul Faustin Seke Etet[3];Jean Marc Muller[4];Giulio Bassi[2];Erique Lukong[5];Raghuveera Kumar Goel[5];Jeremie Mbo Amvene[1];Mauro Krampera[2]
Cancer metastasis;developmental pathways;Notch;Wnt;Hedgehog;therapeutic targets
Master developmental pathways,such as Notch,Wnt,and Hedgehog,are signaling systems that control proliferation,cell death,motility,migration,and stemness.These systems are not only commonly activated in many solid tumors,where they drive or contribute to cancer initiation,but also in primary and metastatic tumor development.The reactivation of developmental pathways in cancer stroma favors the development of cancer stem cells and allows their maintenance,indicating these signaling pathways as particularly attractive targets for efficient anticancer therapies,especially in advanced primary tumors and metastatic cancers.Metastasis is the worst feature of cancer development.This feature results from a cascade of events emerging from the hijacking of epithelial-mesenchymal transition,angiogenesis,migration,and invasion by transforming cells and is associated with poor survival,drug resistance,and tumor relapse.In the present review,we summarize and discuss experimental data suggesting pivotal roles for developmental pathways in cancer development and metastasis,considering the therapeutic potential.Emerging targeted antimetastatic therapies based on Notch,Wnt,and Hedgehog pathways are also discussed.
12-1431/R
ISSN:2095-3941