The role of Toll-like receptors in retinal ischemic diseases

Toll-like receptors(TLRs) are commonly referred to a series of evolutionary conserved receptors which recognize and respond to various microbes and endogenous ligands.Growing evidence has demonstrated that the expression of TLRs in the retina is regulated during retinal ischemic diseases,including i...

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Bibliographic Details
Published in国际眼科杂志：英文版 no. 9; pp. 1343 - 1351
Main Author Wen-Qin Xu Yu-Sheng Wang
Format Journal Article
LanguageEnglish
Published 2016
Subjects
diseases;retinal
ischemic
receptors;retinopathy;retinal
regeneration
Toll-like
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Summary:Toll-like receptors(TLRs) are commonly referred to a series of evolutionary conserved receptors which recognize and respond to various microbes and endogenous ligands.Growing evidence has demonstrated that the expression of TLRs in the retina is regulated during retinal ischemic diseases,including ischemia-reperfusion injury,glaucoma,diabetic retinopathy(DR) and retinopathy of prematurity(ROP).TLRs can be expressed in multiple cells in the retina,such as glial cells,retinal pigment epithelium(RPE),as well as photoreceptor cells and endothelium cells.Activation of TLRs in retina could initiate a complex signal transduction cascade,induce the production of inflammatory cytokines and regulate the level of costimulatory molecules,which play prominent roles in the pathogenesis of retinal ischemic diseases.In this review,we summarized current studies about the relationship between TLRs and ischemic retinopathy.A greater understanding of the effect of TLRs on ischemic injuries may contribute to the development of specific TLR targeted therapeutic strategies in these conditions.
Bibliography:Wen-Qin Xu;Yu-Sheng Wang;Department of Ophthalmology,Eye Institute of Chinese PLA,Xijing Hospital,Fourth Military Medical University
ISSN:2222-3959
2227-4898