环状RNA研究进展及其在口腔疾病中的研究展望

环状RNA（circularRNA）是一类共价闭合环状结构的RNA，具有保守性高、稳定性高、组织特异、广泛存在的特点。环状RNA能发挥miRNA海绵体的作用，调控相应的通路；能与RNA结合蛋白结合，调控基因的表达；环状RNA在疾病组织中的特异性表达，使它有望成为新的疾病诊断标志物和治疗靶点。本文就环状RNA的研究进展作一综述，并展望其在口腔病方面的研究前景。...

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Bibliographic Details
Published in口腔疾病防治 Vol. 25; no. 2; pp. 123 - 128
Main Author 曾秉辉;余东升
Format Journal Article
LanguageChinese
Published 2017
Subjects
环状RNA;肿瘤;口腔病;miRNA海绵体;生物标志物
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Summary:环状RNA（circularRNA）是一类共价闭合环状结构的RNA，具有保守性高、稳定性高、组织特异、广泛存在的特点。环状RNA能发挥miRNA海绵体的作用，调控相应的通路；能与RNA结合蛋白结合，调控基因的表达；环状RNA在疾病组织中的特异性表达，使它有望成为新的疾病诊断标志物和治疗靶点。本文就环状RNA的研究进展作一综述，并展望其在口腔病方面的研究前景。
Bibliography:44-1724/R
Circular RNA; Tumor; Oral diseases; miRNA sponge; Biomarker
Circular RNAs(circRNAs)are RNAs with a covalently closed loop structure,characterized by its conser?vation,stability,tissue specific and ubiquity.CircRNAs can serve as miRNA‘sponges’to modulate the mRNA targetsof miRNAs.CircRNAs can bind with RNA binding proteins and regulate the expression of some genes.The differentialexpression of circRNAs between pathogenic and normal tissues makes circRNAs possibly promising biomarkers for diag?nosis and targets for treatment.In this article,we reviewed the research progress of circRNA and discussed its researchprospects in oral diseases.
ISSN:2096-1456
2097-0234