Structure of unliganded membrane-proxima domains FN4-FN5-FN6 of DCC

Dear Editor, Deleted in colorectal cancer （DCC） is a single pass transmembrane glycoprotein that was originally identified in humans as a candidate tumor suppressor （Fearon et al., 1990）. DCC belongs to the immunoglobulin superfamily, and the extracellular fragment is composed of four immunoglobu- l...

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Published in蛋白质与细胞：英文版 Vol. 8; no. 9; pp. 701 - 705
Main Author Lorenzo I. Finci Jie Zhang Xiaqin Sun Robert G. Smock Rob Meijers Yan Zhang Junyu Xiao Jia-huai Wang
Format Journal Article
LanguageEnglish
Published 2017
Subjects
C结构域
膜
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Summary:Dear Editor, Deleted in colorectal cancer （DCC） is a single pass transmembrane glycoprotein that was originally identified in humans as a candidate tumor suppressor （Fearon et al., 1990）. DCC belongs to the immunoglobulin superfamily, and the extracellular fragment is composed of four immunoglobu- lin-like （Ig-like） domains followed by six fibronectin type III （FN） domains. DCC plays a pivotal role in axon guidance by mediating a combination of attractive and repulsive effects through interactions with the diffusible guidance cue,
Bibliography:11-5886/Q
Dear Editor, Deleted in colorectal cancer （DCC） is a single pass transmembrane glycoprotein that was originally identified in humans as a candidate tumor suppressor （Fearon et al., 1990）. DCC belongs to the immunoglobulin superfamily, and the extracellular fragment is composed of four immunoglobu- lin-like （Ig-like） domains followed by six fibronectin type III （FN） domains. DCC plays a pivotal role in axon guidance by mediating a combination of attractive and repulsive effects through interactions with the diffusible guidance cue
ISSN:1674-800X
1674-8018