糖尿病并发周围神经病变与血清25-羟维生素D_3表达水平的相关性研究

目的探讨糖尿病并发周围神经病变（DPN）与血清25-羟维生素D_3[25-（OH）D_3]表达水平的相关性。方法选取2015年1~12月该院收治的2型糖尿病（T2DM）并发DPN患者45例作为观察组,选取同期收治的T2DM无并发症患者45例作为对照组,检测并比较两组患者血清25-（OH）D_3水平及临床资料,并分析血清25-（OH）D_3水平与DPN发生的相关性。结果观察组患者25-（OH）D_3水平[（38.62±10.14）nmol/L]明显低于对照组[（48.97±12.69）nmol/L],糖化血红蛋白明显高于对照组,病程明显长于对照组,差异均有统计学意义（P〈0.01）;但两组患者B...

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Bibliographic Details
Published in现代医药卫生 Vol. 33; no. 15; pp. 2257 - 2258
Main Author 白秋芳 陈乐菊
Format Journal Article
LanguageChinese
Published 2017
Subjects
25-二羟维生素D_3
周围神经系统疾病
糖尿病,2型
糖尿病神经病变
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Summary:目的探讨糖尿病并发周围神经病变（DPN）与血清25-羟维生素D_3[25-（OH）D_3]表达水平的相关性。方法选取2015年1~12月该院收治的2型糖尿病（T2DM）并发DPN患者45例作为观察组,选取同期收治的T2DM无并发症患者45例作为对照组,检测并比较两组患者血清25-（OH）D_3水平及临床资料,并分析血清25-（OH）D_3水平与DPN发生的相关性。结果观察组患者25-（OH）D_3水平[（38.62±10.14）nmol/L]明显低于对照组[（48.97±12.69）nmol/L],糖化血红蛋白明显高于对照组,病程明显长于对照组,差异均有统计学意义（P〈0.01）;但两组患者BMI值及各项生化指标比较,差异均无统计学意义（P〉0.05）。血清25-（OH）D_3表达水平与DPN的发生呈显著负相关（r=-0.545,P〈0.01）。结论血清25-（OH）D_3的表达水平与T2DM患者是否并发DPN密切相关。
Bibliography:Objective To study the correlation between diabetic peripheral neuropathy（DPN） with serum 25 hydroxy vitamin D_3 [25-（OH）D_3 ] expression level. Methods Forty-five cases of type 2 diabetic mellitus（T2DM） complicating DPN in our hospital from January to December 2015 were selected as the observation group and contemporaneous 45 cases of T2DM with-out complications were served as the control group. The 25-（OH）D_3 level was detected.Then the 25-（OH）D_3 level and clinical data were compared between the two groups. The correlation between serum 25-（OH）D_3 level and DPN occurrence were analyzed. Results The 25-（OH）D_3 level in the observation group was（38.62±10.14）nmol/L,which was significantly lower than（48.97 ±12.69）nmol/L in the control group, the glycosylated hemoglobin level was significantly higher than that in the control group and the disease course in the observation group was significantly longer than that in the control group,the differences were statistically significant（P〈0.01）;but the BMI value and va
ISSN:1009-5519