流感病毒抗原消失时间探讨

目的通过免疫荧光抗原检测技术动态监测流感患儿流感病毒抗原,观察患儿抗原转阴时间和临床症状消失时间,以及两者之间的关系。方法对2016年3-4月就诊于湖南省人民医院的1 063例疑似流感患儿运用甲乙型流感病毒抗原检测试剂盒（免疫荧光法）行流感病毒抗原检测,阳性者予以奥司他韦抗病毒治疗;并嘱咐患者起病后5 d内、5-7 d及7 d后3个时间段复查流感病毒抗原。结果 1 063例疑似流感病例中,流感病毒检出560例（52.68%）。对215例流感病毒阳性患儿进行随访,起病5 d内流感病毒抗原转阴率为9.8%（21例）,5-7 d内累积转阴率为32.1%（69例）,7-10 d累积转阴率为98.1%（...

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Bibliographic Details
Published in中国当代儿科杂志 Vol. 19; no. 5; pp. 564 - 566
Main Author 陈浩峰 钟礼立 方亦兵 陈敏 郭纯 易红玲 陶美婷 黎燕 戴初凤
Format Journal Article
LanguageChinese
Published 2017
Subjects
儿童
抗原消失
流感
症状改善
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Summary:目的通过免疫荧光抗原检测技术动态监测流感患儿流感病毒抗原,观察患儿抗原转阴时间和临床症状消失时间,以及两者之间的关系。方法对2016年3-4月就诊于湖南省人民医院的1 063例疑似流感患儿运用甲乙型流感病毒抗原检测试剂盒（免疫荧光法）行流感病毒抗原检测,阳性者予以奥司他韦抗病毒治疗;并嘱咐患者起病后5 d内、5-7 d及7 d后3个时间段复查流感病毒抗原。结果 1 063例疑似流感病例中,流感病毒检出560例（52.68%）。对215例流感病毒阳性患儿进行随访,起病5 d内流感病毒抗原转阴率为9.8%（21例）,5-7 d内累积转阴率为32.1%（69例）,7-10 d累积转阴率为98.1%（211例）;起病3 d内临床症状改善率为2.8%（6例）,3-5 d临床症状改善累积率为84.7%（182例）,5 d后所有患儿临床症状均得到改善。结论流感患儿经治疗临床症状改善时间早于抗原消失时间;起病7-10 d后流感病毒抗原近100%转阴,推测患儿在起病7-10 d、临床症状消失后返校是相对安全的。
Bibliography:43-1301/R
Influenza; Antigen clearance; Symptom improvement; Child
Objective To investigate the antigen clearance time, time to symptom disappearance, and the association between them using immunofluorescence assay for dynamic monitoring of influenza virus antigen in children with influenza. Methods A total of 1 063 children suspected of influenza who visited the Hunan People＇s Hospital from March to April, 2016 were enrolled. The influenza A/B virus antigen detection kit（immunofluorescence assay） was used for influenza virus antigen detection. The children with positive results were given oseltamivir as the antiviral therapy and were asked to re-examine influenza virus antigen at 5, 5-7, and 7 days after onset. Results Of all children suspected of influenza, 560（52.68%） had an influenza virus infection. A total of 215 children with influenza virus infection were followed up. The clearance rate of influenza virus antigen was 9.8%（21 cases） within 5 days after onset. The cumulative clearance rate of influenza vi
ISSN:1008-8830