Vitamin Pharmacogenomics： New Insight intoIndividual Differences in Diseases and DrugResponses
Vitamins are vital to sustain normal physiological function, metabolism, and growth forall living organisms. Being an integral component of coenzyme, vitamins can affect the catalyticactivities of many enzymes and the expression of drug transporters. Genetic variations in metabo-lism and/or transpor...
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| Published in | 基因组蛋白质组与生物信息学报：英文版 Vol. 15; no. 2; pp. 94 - 100 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
2017
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Vitamins are vital to sustain normal physiological function, metabolism, and growth forall living organisms. Being an integral component of coenzyme, vitamins can affect the catalyticactivities of many enzymes and the expression of drug transporters. Genetic variations in metabo-lism and/or transporter genes of drugs can influence the exposure of the human body to drugs and/or their active metabolites, thus contributing to the variations in drug responses and toxicities.Nonetheless, pharmacogenomics studies on nutrients have been rarely summarized. In this article,we reviewed recent progress on vitamin pharmacogenomics, for a better understanding on the influ-ence of vitamin-related gene polymorphisms on inter-individual differences in diseases and drugefficacy and safety. |
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| AbstractList | Vitamins are vital to sustain normal physiological function, metabolism, and growth forall living organisms. Being an integral component of coenzyme, vitamins can affect the catalyticactivities of many enzymes and the expression of drug transporters. Genetic variations in metabo-lism and/or transporter genes of drugs can influence the exposure of the human body to drugs and/or their active metabolites, thus contributing to the variations in drug responses and toxicities.Nonetheless, pharmacogenomics studies on nutrients have been rarely summarized. In this article,we reviewed recent progress on vitamin pharmacogenomics, for a better understanding on the influ-ence of vitamin-related gene polymorphisms on inter-individual differences in diseases and drugefficacy and safety. |
| Author | Hai-Yan He Mou-Ze Liu Yue-Li Zhang Wei Zhang |
| AuthorAffiliation | Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078,China International Medical Department, Xiangya Hospital, Central South University, Changsha 410008, China ,National Clinical Research Center for Geriatrics, Xiangya Hospital, Central South University, Changsha 410008, China |
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| PublicationTitle | 基因组蛋白质组与生物信息学报：英文版 |
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| Snippet | Vitamins are vital to sustain normal physiological function, metabolism, and growth forall living organisms. Being an integral component of coenzyme, vitamins... |
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| SubjectTerms | difference nucleotide polymorphism;Genetic variation;Individual Vitamin;Pharrnacogenomics;Single |
| Title | Vitamin Pharmacogenomics： New Insight intoIndividual Differences in Diseases and DrugResponses |
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