Vitamin Pharmacogenomics： New Insight intoIndividual Differences in Diseases and DrugResponses

Vitamins are vital to sustain normal physiological function, metabolism, and growth forall living organisms. Being an integral component of coenzyme, vitamins can affect the catalyticactivities of many enzymes and the expression of drug transporters. Genetic variations in metabo-lism and/or transpor...

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Published in基因组蛋白质组与生物信息学报：英文版 Vol. 15; no. 2; pp. 94 - 100
Main Author Hai-Yan He Mou-Ze Liu Yue-Li Zhang Wei Zhang
Format Journal Article
LanguageEnglish
Published 2017
Subjects
difference
nucleotide
polymorphism;Genetic
variation;Individual
Vitamin;Pharrnacogenomics;Single
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Summary:Vitamins are vital to sustain normal physiological function, metabolism, and growth forall living organisms. Being an integral component of coenzyme, vitamins can affect the catalyticactivities of many enzymes and the expression of drug transporters. Genetic variations in metabo-lism and/or transporter genes of drugs can influence the exposure of the human body to drugs and/or their active metabolites, thus contributing to the variations in drug responses and toxicities.Nonetheless, pharmacogenomics studies on nutrients have been rarely summarized. In this article,we reviewed recent progress on vitamin pharmacogenomics, for a better understanding on the influ-ence of vitamin-related gene polymorphisms on inter-individual differences in diseases and drugefficacy and safety.
Bibliography:11-4926/Q
ISSN:1672-0229