含1,3,4-噻二唑的吡啶联吡唑乙酰胺类化合物的合成及除草活性

以乙酰丙酮、溴乙酸乙酯和2,6-二氯吡啶为起始原料,经取代、肼基化、环合、水解、酸化及缩合等反应,得到9个未见文献报道的吡啶联吡唑乙酰基类化合物B1～B9。其结构均经核磁共振氢谱和质谱表征。初步生物活性测定表明：在150 g/hm2的处理剂量下,大部分目标化合物表现出一定的除草活性,其中化合物B2、B3、B6和B8对苘麻Abutilon theophrasti Medicus、反枝苋Amaranthus retroflexus和凹头苋Amaranthus lividus L.生长的抑制率接近100%。...

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Published in农药学学报 Vol. 19; no. 1; pp. 114 - 118
Main Author 胡燕红 何海琴 刘幸海 翁建全 谭成侠
Format Journal Article
LanguageChinese
Published 2017
Subjects
1,3,4-噻二唑
乙酰胺类衍生物
合成
吡啶联吡唑
除草活性
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ISSN1008-7303

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Summary:以乙酰丙酮、溴乙酸乙酯和2,6-二氯吡啶为起始原料,经取代、肼基化、环合、水解、酸化及缩合等反应,得到9个未见文献报道的吡啶联吡唑乙酰基类化合物B1～B9。其结构均经核磁共振氢谱和质谱表征。初步生物活性测定表明：在150 g/hm2的处理剂量下,大部分目标化合物表现出一定的除草活性,其中化合物B2、B3、B6和B8对苘麻Abutilon theophrasti Medicus、反枝苋Amaranthus retroflexus和凹头苋Amaranthus lividus L.生长的抑制率接近100%。
Bibliography:11-3995/S
1; 3; 4-thiadiazole; pyridyl substituted pyrazole; acetamide derivatives; synthesis; herbicidal activity
Nine novel 2-（1-（3-chloro pyridin-2-yl）-3,5-dimethyl-1H-pyrazol-4-yl） acetic acid derivatives B1-B9 were synthesized from acetylacetone, ethyl bromoacetate and 2,6-dichloropyridine. The synthesis route included a series of reactions such as substitution, alkylation, cyclization, hydrolysis,and acidification condensation. The chemical structures were characterized by ^1H NMR and MS.Preliminary bioassay showed that most of the above compounds displayed herbicidal activities at the concentration of 150 g/hm^2. The inhibition rates of B2, B3, B6 and B8 against Abutilon theophrasti Medicus, Amaranthus retroflexus and Amaranthus lividus L. were nearly 100%.
HU Yanhong, HE Haiqing, LIU Xinghai, WENG Jianquan, TAN Chengxia （College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China）
ISSN:1008-7303