Aerobic Alcohol Ammoxidation Catalyzed by Copper（I）/Amino Acid： a Scalable Protocol to Nitriles

A facile, practical and scalable catalyst system for alcohols ammoxidation into nitriles was developed using amino acid as ligand, oxygen as terminal oxidant and copper iodide（CuI） as catalyst. The catalyst system shows excellent functional groups compatibility for a wide range of testing substrates...

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Bibliographic Details
Published in高等学校化学研究：英文版 no. 4; pp. 586 - 593
Main Author ZHANG Guofu ZHANG Guihua LEI Jie LI Shasha XU Shengjun DING Chengrong SHAN Shang
Format Journal Article
LanguageEnglish
Published 2016
Subjects
催化剂体系
协议
可扩展
好氧
氧化催化
氨基酸
醇
铜（I）
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Summary:A facile, practical and scalable catalyst system for alcohols ammoxidation into nitriles was developed using amino acid as ligand, oxygen as terminal oxidant and copper iodide（CuI） as catalyst. The catalyst system shows excellent functional groups compatibility for a wide range of testing substrates, even the substrates bearing oxidationsensitive groups such as MeS-, alkenyl and --NH2 can also work well. In addition, the protocol is readily scaled up to more than 20 g and the product can be obtained just through filtration or distillation without conventional column chromatography.
Bibliography:22-1183/O6
Alcohol; Amino acid; Nitrile; Copper iodide; Scale up
A facile, practical and scalable catalyst system for alcohols ammoxidation into nitriles was developed using amino acid as ligand, oxygen as terminal oxidant and copper iodide（CuI） as catalyst. The catalyst system shows excellent functional groups compatibility for a wide range of testing substrates, even the substrates bearing oxidationsensitive groups such as MeS-, alkenyl and --NH2 can also work well. In addition, the protocol is readily scaled up to more than 20 g and the product can be obtained just through filtration or distillation without conventional column chromatography.
ISSN:1005-9040
2210-3171